C. Resende Oliveira

Catarina Isabel Neno Resende de Oliveira awarded her MD PhD in Neurology in 1984 at the University of Coimbra.

Full Professor of Biochemistry at the Faculty of Medicine, University of Coimbra and Consultant of Neurology at the Neurological Clinic, in the Coimbra University Hospital,  she is President of the Scientific Council of the Faculty of Medicine, University of Coimbra, and director of the Center for Neuroscience and Cell Biology of Coimbra where she coordinates the scientific area of Neuroscience and Disease.
Research in this area has been particulary effective in the understanding of the molecular Mechanismes of Neuroprotection and in promoting translation research of Neurodegeneration disorders.

Her main interst in research is focused in the mechanisms of aging and in the disorders for which aging is a risk factor, trying to elucidate the molecular mechanisms of neurodegeneration induced by amyloidogenic peptides, particularly on the signalling role of mitochondria in a neuronal death.

She has coordinated several scientific projects on brain aging and dementia; cellular response to oxidative stress and cell signalling, mitochondrial function and relationship between diabetes and neurodegerative disorders.

Her contributions to science are described in over 200 publications, dealing with biochemical, molecular and genetic studies aiming to elucidate the mechanisms of neurodegeneration, occurring in prion and Alzheimer’s dementia, in order to identify biomarkers of disease and new targets for therapeutical intervention.

During her carreer in science, she supervised 17 PhD students and 17 Master students.
She has been reviewer for FCT Welcome Trust and Alzheimer´s Association is and Associate Editor of Journal of Alzheimer´s Disease.

In 2006 she awarded the Prize ” Estímulo à Excelência “, Fundação para a Ciência e Tecnologia (FCT), and in 2008 the Prize “ Nunes Correa Verdades de Faria” in Aging, Santa Casa da Misericórdia de Lisboa.

12 relevant publications (selected list in a total of 235)

 Rego AC, Santos MS, Oliveira CR.
Oxidative stress, hypoxia, and ischemia-like conditions increase the release of endogenous amino acids by distinct mechanisms in cultured retinal cells.
J Neurochem. 1996 Jun;66(6):2506-16.
Nº de citações: 72   |   Factor de Impacto: 4,90

Cardoso SM, Pereira C, Oliveira R.
Mitochondrial function is differentially affected upon oxidative stress.
Free Radic Biol Med. 1999 Jan;26(1-2):3-13.
Nº de citações: 62   |   Factor de Impacto: 4,116

Cardoso SM, Santos S, Swerdlow RH, Oliveira CR.
Functional mitochondria are required for amyloid beta-mediated neurotoxicity.
FASEB J. 2001 Jun;15(8):1439-41
Nº de citações: 65   |   Factor de Impacto: 8,817

Rego AC, Oliveira CR.
Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases.
Neurochem Res. 2003 Oct;28(10):1563-74. Review.
Nº de citações: 119   |   Factor de Impacto: 1.511

Moreira PI, Santos MS, Moreno AM, Seiça R, Oliveira CR.
Increased vulnerability of brain mitochondria in diabetic (Goto-Kakizaki) rats with aging and amyloid-beta exposure.
Diabetes. 2003 Jun;52(6):1449-56.
Nº de citações: 18   |   Factor de Impacto: 8,298

Cardoso SM, Proença MT, Santos S, Santana I, Oliveira CR.
Cytochrome c oxidase is decreased in Alzheimer's disease platelets.
Neurobiol Aging. 2004 Jan;25(1):105-10.
Nº de citações: 43   |   Factor de Impacto: 5,516

Cardoso SM, Santana I, Swerdlow RH, Oliveira CR.
Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity.
J Neurochem. 2004 Jun;89(6):1417-26.
Nº de citações: 56   |   Factor de Impacto: 4,824

Pereira C, Agostinho P, Moreira PI, Cardoso SM, Oliveira CR.
Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies.
Curr Drug Targets CNS Neurol Disord. 2005 Aug;4(4):383-403. Review
Nº de citações: 27   |   Factor de Impacto: 4,389

Duarte AI, Proença T, Oliveira CR, Santos MS, Rego AC.
Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress.
Diabetes. 2006 Oct;55(10):2863-70.
Nº de citações: 11   |   Factor de Impacto: 7,955

Ferreiro E, Costa R, Marques S, Cardoso SM, Oliveira CR, Pereira CM.
Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP(106-126).
J Neurochem. 2008 Feb;104(3):766-76. Epub 2007 Nov 6.
Nº de citações: 1   |   Factor de Impacto: 4,451

Guerreiro RJ, Santana I, Brás JM, Revesz T, Rebelo O, Ribeiro MH, Santiago B, Oliveira CR, Singleton A, Hardy J.
Novel progranulin mutation: screening for PGRN mutations in a Portuguse series of FTD/CBS cases
Mov Disord.2008 Jul 15;23(9):1269-73

Camargos S, Scholz S, Simón-Sánchez J, Paísan-Ruiz C, Lewis P, Hernandez D, Ding J, Gibbs JR, Cookson MR, Bras J, Guerreiro R, Oliveira CR, Lees A, Hardy J, Cardoso F, Sngleton AB.
DYT16, a novel young-onset dystonia-parkinson disorder: identification of a segregating in the stress- response protein PRKRA.
Lancet Neurol. 2008 Mar;7(3):207-15. Epub 2008 Feb 1.